Roxana Cojocariu, Viorica Rarinca, Cătălina Ionescu
ABSTRACT :
Regarding the complicated gut-brain axis, the article foocuses on the zebrafish model as a valuable tool for studying the gut-brain-microbiota interaction. Thus, we
focused on the bidirectional correlations between gut microbiota and stress-related behaviour, the impact of stress on gastrointestinal disorders, and the involvement
of the microbiome in the stress response. On the other hand, the genetic and physiological similarities of the zebrafish model to humans make it suitable for studying diseases related to the gut-brain axis. Additionally, functional gastrointestinal disorders (FGIDs) such as the irritable bowel syndrome (IBS) using zebrafish models highlight the potential for new insights into these conditions. Thus, we emphasized the importance of factors such as diet, environment, genetics and the impact of stress on the gut-brain axis, shedding light on the complex interaction between gut, brain and microbiota in influencing various physiological processes and diseases.