Cătălina IONESCU, Ioana FARCAŞ, Alin CIOBICA, Manuela PĂDURARIU, Sorin CÎMPEANU, Mirela CÎMPEANU, Lucian GORGAN
ABSTRACT :
The present study, focusing on quantifying apoptotic levels in nerve cells in mice with induced autism, was divided into two stages based on the nature of the conducted tests. In the initial phase, presented here, behavioral tests were conducted on both the autism animal models and individuals from the control group. Subsequently, genetic tests were performed on nerve tissue collected from these animals, with further relevance and to present later on. The study of apoptotic levels in nerve cells in mice with induced autism was conducted in the Molecular Genetics Laboratory of the Faculty of Biology, “Alexandru Ioan Cuza” University of Iaşi. The results of behavioral tests and genetic tests suggest the possibility that prenatal treatment with valproic acid at a dose of 500 mg/kg induces the autistic syndrome in an animal model through anatomical rather than molecular deficits.